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Guillain-Barrœ Strohl syndrome is an inflammatory polyneuropathy which is classically referred to as a monophasic, symmetrically progressive, ascending paralysis preceded by illness or inoculation. The clinical manifestations have been attributed to immune-mediated destruction of peripheral nerve myelin. Current research has been directed at the pathogenesis and immunology of the disease. With the discovery of favorable responses to plasmapheresis and gamma globulin, there has been renewed interest in the humoral and cellular aspects of the disorder.
The features of clinical Guillain-Barrœ syndrome include:
Antecedent infections, inoculations and surgeries have been described. Infectious agents include campylobactor; HIV; gastrointestinal and respiratory viruses; and mycoplasm. The mortality rate, which ranges from 1% to 8%, is due to respiratory failure, intervening infections, autonomic dysfunction and pulmonary emboli. While 15% have residual deficits, 85% recover completely.
Other disorders which mimic Guillain-Barrœ syndrome include polio, botulism, HIV, diptheria, tic paralysis, myasthenia gravis, hypophosphatemia, heavy metal poisoning, cingulotoxin poisoning, sarcoid and rheumatologic disorders.
The complete version of this article was original published in the "CNI REVIEW" medical journal, Winter 1992, page 22.
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Colorado Neurological
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