Diagnostic Techniques, Part 1
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Fall 1990
Volume 1, Number 2
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Abstracts
of this issue appear
below. Send e-mail or call 303-788-4010 to order a printed copy.
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 Abstracts
The Clinical
Usage of Magnetic Resonance Characterization of Blood and
Blood Flow
James N. Dreisbach, MD, Mark Brown, PhD
Magnetic
resonance imaging is beginning to add a new dimension to
neuroimaging with the development of magnetic resonance
angiography and the ability to date hemorrhage, document
blood vessel patency and diagnose blood vessel
abnormalities. This article shows the evolving usage of
MR int he management of neurovascular disease and some of
the underlying MR physical principles.
Carotid
Non-Invasive Vascular Assessment
A. Thomas Stavros, MD
Duplex
sonography is an efficacious and reproducible way to
demonstrate the presence and severity of extracranial
carotid atherosclerotic disease. The overall accuracies
are competitive with all other modalities, including
angiography, within the scan-accessible portions of the
bifurcation areas. The best criteria for grading
hemodynamically significant stenosis are: 60 to 79%
stenosis = systolic ratio of 1.8 or greater and
end-diastolic velocity of 105 cm/sec or less; 80% or
greater stenosis = end-diastolic velocity of 105 cm/sec
or greater. The exam is hampered by limited access to
areas above the mandible and below the clavicle, and
indirect flow disturbances caused by distal and proximal
lesions can be detected only if severe. Duplex sonography
is also limited by its tendency to overall complete
occlusion, although Color Doppler Imaging is improving
this somewhat. Duplex sonography is less efficacious for
detection of intraplaque hemorrhage than it is for degree
of stenosis.
Modern Trends
in Analyses of Chemical and Cellular Components of
Cerebrospinal Fluid
Eleanor B. Sinton, MD, D.C. Reimann, PhD, Ronald S.
Murray, MD
Cerebrospinal
fluid can provide the clinician with information
concerning the diverse immune and biochemical responses
of the central nervous system. As a result of rapidly
advancing technology, laboratory analyses of spinal fluid
have reached new levels of accuracy and sophistication.
This report describes the "cutting edge" of
test modalities including applications of high resolution
gel electrophoresis, immunofixation electrophoresis, flow
cytometry and nuclear magnetic resonance spectroscopy.
Data is presented regarding the intrathecal immune
response observed in patients examined at the Rocky
Mountain Multiple Sclerosis Center.
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