Frontiers of Movement Disorders
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Spring 1994
Volume 5, Number 1
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Abstracts
of this issue appear
below. Send e-mail or call 303-788-4010 to order a printed copy.
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 Abstracts
Neurological
Basis of Movement Disorders
Christopher F. O’Brien, MD
Our
understanding of the clinical spectrum, physiology, and
treatment of movement disorders has radically changed
over the past 20 years. This article reviews the more
common movement disorders, along with the related
anatomy, neurochemistry, therapeutic agents,
pharmacology, surgical options, rehabilitation, and
directions for future research.
Focal
Dystonias and Botulinum Toxin
Christopher F. O’Brien, MD
Focal
dystonias and the 4 main categories of treatment are
reviewed. An expanded discussion of treatment with
botulinum toxin follows, covering the pharmacology,
applications, and treatment outcomes of botulinum toxin
injections to treat various types of dystonia.
Fetal
Transplants for Parkinson’s Disease
Curt R. Freed, MD, Robert E. Breeze, MD, Neil L.
Rosenberg, MD, Christopher F. O’Brien, MD, Stuart A. Schneck, MD
In an effort
to restore more normal function to patients with advanced
Parkinson’s disease, implantation of embryonic
mesencephalic tissue containing dopamine cells was
introduced into the caudate and putamen of 14 patients.
Most patients experienced improvement after the
procedure. Such improvement was observed by 3 months
post-surgery and persisted up to 5 years. The drug dosage
required was reduced by 50%. Improvement on the Hoehn and
Yahr scale averaged approximately 1 stage (ie, from a
rating of 4 to 3).
Surgical
Treatment of Movement Disorders
Cynthia L. Norrgran, MD
Surgical
treatment is a viable option for many patients with
movement disorders. Advances in surgical technique,
imaging, and localization have improved surgical results.
Community
Resources for Movement Disorders
Laura J. Watt, RN
Physicians
have limited time and resources to help the patient and
family address the comprehensive emotional and
psychological issues that accompany a chronic movement
disorder. Numerous national and local resources are
available to assist the patient. A list of national, as
well as Colorado, movement disorder organizations is
provided.
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